The production of Hb F after birth is an important factor in modifying the clinical severity of beta thalassemia because an increased gamma-globin level will bind the additional a-globin and form Hb F. The objective of this project is to evaluate the association of Hb F level with phenotypic diversity of patients with beta thalassemia.
Study Type
OBSERVATIONAL
Enrollment
1,200
Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio- Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).
Southern Medical University
Guangzhou, Guangdong, China
RECRUITINGHb F level and severity of anemia
Observational study that analyzed association of Hb F level and anemia severity in patients
Time frame: 3 years
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