Skin Sympathetic Nerve Activity and Cardiac Arrhythmia

University Hospital, Bordeaux100 enrolled

Overview

Sympathetic tone is important in cardiac arrhythmogenesis. The simultaneous recording of sympathetic nerve activity (SNA) and electrocardiogram (ECG) was obtained by invasive method. The purpose of this protocol is to further develop this recording method to turn it into a new non-invasive tool for arrhythmia prediction and detection. This method may also be useful in validating the results of surgical procedures aimed at sympathetic denervation

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Sudden Death Ventricular Tachycardia Persistent Atrial Fibrillation

Interventions

SKNA recordingDEVICE

The coupled recording of the sympathetic nervous activity of the skin and of an ECG will be carried out using the ME6000 device, CE marked, from the Bittium company. It will be performed for a maximum period of one hour at Day 1, Post-procedure between Day 1 and discharge from hospital, and month 6

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- patient hospitalized at Bordeaux University Hospital for sudden death, ventricular tachycardia, persistent or paroxysmal atrial fibrillation treated by ablation and/or vein of Marshall ethanol infusion Exclusion Criteria: * pregnancy, * patient under 18 year old, * patient with a cardiac stimulation device

Locations (1)

Bordeaux University Hospital

Pessac, France

Outcomes

Primary Outcomes

Delay between the discharge of the sympathetic system and the rhythmic event.

Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed.

Time frame: Day 1

Delay between the discharge of the sympathetic system and the rhythmic event.

Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed.

Time frame: Day 2

Delay between the discharge of the sympathetic system and the rhythmic event.

Temporal correlation of occurrence of sympathetic electrical event and cardiac arrhythmia by the MacNemar test will be performed.

Time frame: Month 6

Data from ClinicalTrials.gov

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