Adjuvant Chemotherapy and Anti-PD-1 Antibody in Patients With Stage IIIC2-IVB Cervical Cancer

Inclusion Criteria: 1. Written informed consent obtained from the subject prior to any protocol-related procedures. 2. Aged 18-75 years(including 18 years old and 75 years old). 3. Bodyweight of greater than 30 kg. 4. Must have an average life expectancy of 6 months. 5. Histologically or cytologically confirmed advanced/metastatic cervical cancer. 6. Eastern Cooperative Oncology Group (ECOG) ≤ 2 or Karnofsky Performance Status of ≥ 60. 7. Participants must have normal organ and marrow function as defined below: (Hgb \>=9g/dl, Absolute neutrophil count ≥1500/mcL, Platelets ≥100000/mcL, Total bilirubin \<=1.5 x normal institutional limits, AST(SGOT)/ALT(SGPT) ≤3 × institutional upper limit of normal, Creatinine clearance \>40 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976). \- Exclusion Criteria: 1. Female patients who are pregnant or breastfeeding or female patients of reproductive potential who are not willing to employ effective birth control. 2. History of prior malignancy within 2 years prior to screening, with the exception of those with a negligible risk of metastasis or death (e.g., 5-year OS of \> 90%), such as but not limited to, non-melanoma skin carcinoma, ductal carcinoma in situ, or stage I endometrioid uterine cancer, and others at the discretion of the Principal Investigator (PI). 3. Subject has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Subjects with previously treated brain metastases are permissible. Patients with untreated brain metastases, spinal cord compression, or leptomeningeal carcinomatosis are excluded from this clinical trial because of their poor prognosis, because of symptoms that may arise from inflammatory reactions, and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. Patients with brain metastases or spinal cord compression previously treated with radiation and/or surgery are allowed if local treatment was \>30 days ago, most recent MRI demonstrates stability or decrease in size of all lesions, and the patient has no current neurologic symptoms related to the metastases and treatment and no requirement for corticosteroids related to the prior treatment. 4. Prior oncology vaccine therapy. 5. History of allogeneic organ transplantation. 6. Subject has an immunodeficiency. (1) Treatment with systemic immunosuppressive medication (including, but not limited to, corticosteroids, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor (TNF)-α agents) within 2 weeks prior to initiation of study treatment, or anticipation of the need for systemic immunosuppressive medication during the course of the study, with the following exceptions: Patients who received acute, low-dose systemic immunosuppressant medication（exceed 10 mg/day of prednisone or its equivalent） or a one-time pulse dose of systemic immunosuppressant medication (e.g., 48 hours of corticosteroids for a contrast allergy) Patients who received mineralocorticoids (e.g., fludrocortisone), corticosteroids for chronic obstructive pulmonary disease or asthma, or low-dose corticosteroids for orthostatic hypotension or adrenal insufficiency. (2)Subject has an active autoimmune disease in the past 2 years. (3)Active or history of autoimmune disease or immune deficiency, including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, or multiple sclerosis with the following exceptions: Patients with a history of autoimmune-related hypothyroidism who are on the thyroid replacement hormone are eligible for the study; Patients with controlled type 1 diabetes mellitus who are on an insulin regimen are eligible for the study. 7.Treatment with a vascular endothelial growth factor (VEGF) inhibitor within the last 6 weeks. 8.Major surgical procedure (as defined by the treating physician) within 28 days prior to the first dose of ICIs or still recovering from prior surgery. 9.Active or prior documented interstitial lung disease. 10.History of hypersensitivity to ICIs or any CTLA4, PD1, or PDL-1 inhibitor. 11.Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination, and radiographic findings, and tuberculosis \[TB\] testing in line with local practice), hepatitis B (known positive hepatitis B virus \[HBV\] surface antigen \[HBsAg\] result), hepatitis C, or human immunodeficiency virus (positive HIV 1/2 antibodies); patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody \[anti-HBc\] and absence of HBsAg) are eligible; patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV ribonucleic acid (RNA). 12.History of prior bowel fistula, ulcerations, or perforations. 13.Any medical, psychological, or social condition that in the opinion of the treating physician would interfere with the evaluation of the investigational product or interpretation of subject safety or study results.