The purpose of this study is to determine whether combination of orbital compression surgery with strabismus surgery is better than strabismus surgery after orbital compression surgery in the treatment of moderate-to-severe thyroid associated ophthalmopathy
This study will be a interventional case series. Patients with moderate-to-severe thyroid associated ophthalmopathy will be randomized to receive combination of orbital compression surgery with strabismus surgery or strabismus surgery after orbial compression surgery.Patients will be followed for 6 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
combination of orbital compression surgery and strabismus surgery at the same time
orbital compression
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China
quality of life ,measured by GO-QoL(quality of life with Grave's Orbitopathy) .
All GO-QoL questions were scored as 'severely limited' (one point), 'a little limited' (two points) or 'not limited at all' (three points). The questions 1-8 for visual functioning (VF) and questions 9-16 for appearance (AP)were summed to produce two raw scores from 8 to 24 points and then transformed to two total scores from 0 to 100 by the following formula: total score = \[(raw score - 8)/16 9 100\]. In both cases, higher total scores indicate better QoL. When there were missing values, total scores were calculated for the remaining completed items. The transformation was then adjusted to total score = \[(raw score - \*)/(2x\*) x100\] where \* is the number of completed items.
Time frame: 6 weeks after surgery
quality of life, measured by GO-QoL(quality of life with Grave's Orbitopathy) .
All GO-QoL questions were scored as 'severely limited' (one point), 'a little limited' (two points) or 'not limited at all' (three points). The questions 1-8 for visual functioning (VF) and questions 9-16 for appearance (AP)were summed to produce two raw scores from 8 to 24 points and then transformed to two total scores from 0 to 100 by the following formula: total score = \[(raw score - 8)/16 9 100\]. In both cases, higher total scores indicate better QoL. When there were missing values, total scores were calculated for the remaining completed items. The transformation was then adjusted to total score = \[(raw score - \*)/(2x\*) x100\] where \* is the number of completed items.
Time frame: 6 months
strabismus status
angle of deviation including up-gaze, down-gaze ,left and right-gaze
Time frame: 6 weeks after surgery
strabismus status
angle of deviation including up-gaze, down-gaze ,left and right-gaze
Time frame: 6 months after surgery
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