N-ACETYLCYSTEINE FOR THROMBOLYSIS IN ACUTE STROKE

Inclusion Criteria: * Patient presenting with an acute ischemic stroke (non lacunar) as assessed by cerebral imaging (either CT or MRI), with or without visible vessel occlusion. * Patient eligible to intravenous thrombolysis according to current criteria, including patients who will also benefit from endovascular treatment (if eligible). * Personal or familial consent to participate in the study. Exclusion Criteria: * Known hypersensitivity to N-Acetylcysteine or to any excipient from the formulation. * Coma and/or NIHSS \<4 or ≥20. * Daily treatment with Nitrovasodilator before the inclusion. * Known asthma or chronic obstructive pulmonary disease requiring bronchodilatators or steroids. * Participation to another interventional study if it requires administration of an experimental treatment in the first 3 days after NAC treatment. * Women of childbearing age (age \< or = to 50) * Known history of prior treatment with vitamin-K antagonist or direct oral anticoagulant. * Known history of severe hepatopathy including cirrhosis, portal hypertension (esophageal varices) and evolutive hepatopathy.