This project is a multicenter pilot project to evaluate the therapeutic success in the long term up to 3 months after a delirium in a recovery room. There is a Europe-wide recommendation for the prevention of postoperative delirium in older patients and the evidence and consensus-based guideline "Management of delirium, analgesia and sedation in intensiv care medicine" of the AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften) are regularly updated for the detection and treatment of delirium in the intensive care unit. The aim is to evaluate the effects of a systematic delirium screening and the delirium treatment options in the long term in the same way as the current recommendations for the patient cohort of the recovery room.
Study Type
OBSERVATIONAL
Enrollment
5
Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin
Berlin, Germany
Morbidity
Postoperative complications according to Clavien-Dindo classification
Time frame: Up to three months
Duration of delirium
Duration of delirium is measured in days
Time frame: Time until discharge from recovery room, an expected average of 5 days
Incidence of delirium
Postoperative delirium rate, defined according to Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and/or as ≥ 2 cumulative points in the Nursing Delirium Screening Scale (Nu-DESC) and/or a positive Confusion Assessment Method (CAM) and/or Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) score and/or patient chart review that shows descriptions of delirium.
Time frame: Time until discharge from recovery room, an expected average of 5 days
Preventive measures against delirium 1
Preventive measures of delirium are measured by medical treatments
Time frame: Time until discharge from recovery room, an expected average of 5 days
Preventive measures against delirium 2
Preventive measures of delirium are measured by non-medical treatments
Time frame: Time until discharge from recovery room, an expected average of 5 days
Anticholinergic drugs
Measured by anticholinergic drug scale
Time frame: Time until discharge from hospital, an expected average of 7 days
Treatment of delirium
Treatment of delirium with medication
Time frame: Time until discharge from hospital, an expected average of 7 days
Measurement of acetylcholinesterase
Measurement of activities of the enzyme - acetylcholinesterase in blood
Time frame: Time until discharge from recovery room, an expected average of 5 days
Measurement of butyrylcholinesterase
Measurement of activities of the enzyme - butyrylcholinesterase in blood
Time frame: Time until discharge from recovery room, an expected average of 5 days
Chronic comorbid diseases
Chronic comorbid diseases (comorbidities) are measured by Charlson comorbidity index
Time frame: Time until discharge from hospital, an expected average of 7 days
Health related quality of life
EQ-5D
Time frame: Up to three months
Treatment of vegetative symptoms
Treatment of vegetative symptoms is measured by vegetative medical therapy
Time frame: Time until discharge from recovery room, an expected average of 5 days
Treatment of pain
Treatment of pain is measured by analgesia
Time frame: Time until discharge from recovery room, an expected average of 5 days
Treatment of postoperative vomiting
Treatment of postoperative vomiting is measured by anti-emetics
Time frame: Time until discharge from recovery room, an expected average of 5 days
Treatment of productive psychotic symptoms
Treatment of productive psychotic symptoms is measured by anti-psychotics
Time frame: Time until discharge from recovery room, an expected average of 5 days
Treatment of anxiety
Treatment of anxiety is measured by anxiolytics
Time frame: Time until discharge from recovery room, an expected average of 5 days
Treatment of sleep disorders
Treatment of sleep disorders are measured by sleeping drugs
Time frame: Time until discharge from recovery room, an expected average of 5 days
Number of participants with changes in laboratory values
Routine laboratory results were planned to be documented in the hospital including hemoglobin, lymphocytes, total neutrophils, platelet count and white blood cell (WBC) count from blood samples.
Time frame: Time until discharge from hospital, an expected average of 7 days
Apache II
APACHE II score is measured by the Acute Physiology and Chronic Health Evaluation System II.
Time frame: Time until discharge from intensive care unit, an expected average of 6 days
SOFA
SOFA is measured by Sequential Organ Failure Assessment.
Time frame: Time until discharge from intensive care unit, an expected average of 6 days
SAPS II
SAPS II is measured by Simplified Acute Physiology Score II.
Time frame: Time until discharge from intensive care unit, an expected average of 6 days
Intensive care unit stay
Intensive care unit stay is measured in days
Time frame: Time until discharge from intensive care unit, an expected average of 6 days
Hospital stay
Hospital stay is measured in days
Time frame: Time until discharge from hospital, an expected average of 7 days
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