Sequential Dose-escalation Study to Assess the Safety, Tolerability and Pharmacokinetics of TB006 in Healthy Subjects

Inclusion Criteria: * Healthy volunteers, male or female 18-55 at the time of informed consent * In good health as determined by the principal investigator * Body weight of ≥ 50 kg and BMI within the range 18-30 kg/m2 (inclusive). * Chinese subjects are eligible to be included in the study if all of the following criteria apply in addition to the above: Must have been born in China, with 2 Chinese biological parents and 4 Chinese grandparents as confirmed by interview; Must have lived no more than 10 years outside of China; Must not have changed their lifestyle or habits significantly, including diet, since leaving China. Exclusion Criteria: * Any current history of clinically significant disease in the opinion of the investigator or receiving maintenance medications on a daily basis. * Any active or unstable clinically significant medical or psychiatric condition as judged by the investigator. * Smokes cigarettes or uses other nicotine-containing products (eg, snuff, nicotine patch, nicotine chewing gum, mock cigarettes, or inhalers), and has done so in the 3 months prior to screening. * Regular alcohol consumption within 6 months prior to the study defined as: an average weekly intake of \> 20 units for males or \> 16 units for females. One unit is equivalent to 8 glasses of alcohol: a half pint (∼240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.