Multi-center Observational Study on the Progression of Atherosclerotic Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up

Inclusion Criteria: 1. The age is 18-90 years old (including 18 and 90 years old); 2. The subjects knew about the experiment and signed the informed consent voluntarily; 3. The subjects complicated with tumor diseases and atherosclerotic plaques; 4. The subjects received regular PD-1 inhibitor treatment; 5. The subjects had ultrasound images of atherosclerotic plaques before- and after- or during PD-1 blockade treatment at the two different timepoints; 6. The subjects received regular treatments of PD-1 inhibitor during the two timepoints of artery ultrasound examinations; 7. The subjects who had ultrasound images before the initiation of first-dose PD-1 inhibitor, the interval between these two timepoints should be restricted within 1 month; 8. The subjects who had ultrasound images after 3 months of PD-1 inhibitor treatment. Exclusion Criteria: 1. Subjects stop receiving PD-1 inhibitor treatments during follow-up; 2. Subjects are reluctant to continue to be involved in this study; Known pregnant and lactating women; 3. Plaque areas can not be calculated because of the quality of ultrasound image; 4. Other situations that the researchers judged were not suitable for inclusion.