Total Parathyroidectomy With Autotransplantation Versus Total Parathyroidectomy Alone for Secondary Hyperparathyroidism

The Second Hospital of Nanjing Medical University200 enrolled

Overview

Total parathyroidectomy with autotransplantation (TPTX+AT) and Total parathyr- oidectomy alone (TPTX) are the common surgical procedures.The purpose of the study was to compare the long-term benefits of surgery between the two groups.

The trial was performed as a nonconfirmatory randomized controlled pilot trial with 200 patients on long-term dialysis with otherwise uncontrollable SHPT to generate data on the rate of recurrent disease within a 5-year follow-up period after TPTX or TPTX+AT. Parathyroid hormone (PTH) and calcium levels, recurrent or persistent hyperparathyroidism, parathyroid reoperations, morbidity, and mortality were evaluated during a 5-year follow-up.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

200

Conditions

Secondary Hyperparathyroidism;Parathyroidectomy

Interventions

ParathyroidectomyPROCEDURE

Total Parathyroidectomy With Autotransplantation or Total Parathyroidectomy Alone

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: Severe renal secondary hyperparathyroidism Exclusion Criteria: Patients with diabetes a history of chronic inflammatory disease a history of malignant tumor a history of kidney transplantation a history of neck surgery a history of alcohol abuse a history of drug abuse inability to cooperate with the participants refusal to participate in the study

Locations (1)

NanjingMU

Nanjing, China

RECRUITING

Outcomes

Primary Outcomes

the rate of recurrent

Time frame: 60 months

Central Contacts

Mingxia XIONG, Ph.D

CONTACT

13951880995 xiongmingxia@njmu.edu.cn

Data from ClinicalTrials.gov

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