the Application of Diffusion Tensor Imaging in the Evaluation of Peripheral Neuropathy in ANCA Associated Vasculitis

Second Affiliated Hospital, School of Medicine, Zhejiang University50 enrolled

Overview

1. Include qualified 50 ANCA-associated vasculitis(AAV) patients; and the first 27 patients will be divided into 3 groups with different diffused tension image (DTI) parameters and to choose the best strategy； 2. On baseline, 6 months after treatment and 24 months after treatment, the AAV patients will accomplish the Birming-ham vasculitis activity score(BVAS) besides DTI； 3. The new serum biomarkers of AAV associated peripheral neuropathy will be measured by ELISA； (4) Another cohort with 50 patients with AAV associated peripheral neuropathy who were evaluated by traditional methods (electromyogram) and compared to the patients cohort that evaluated using DTI by cost-benefit analysis

Study Type

OBSERVATIONAL

Enrollment

Conditions

ANCA Associated Vasculitis

Interventions

diffusion tensor imaging(DTI) evaluationOTHER

DTI is a new kind of MRI technique to evaluate peripheral neuropathy

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18-80 years old； * must fulfill 2012 criteria of ANCA associated vasculitis * presented with peripheral neuropathy diagnosed by specialists Exclusion Criteria: * the ANCA associated vasculitis is already in the stable stage after treatments * any vital organ dysfunction * active infection or cancer * can not finish DTI scan

Outcomes

Primary Outcomes

To assess the optimal b-value (a key parameter) for DTI in AAV associated peripheral neuropathy

b-value is a key technique parameter for DTI, which will decide the quality of DTI image

Time frame: 2 years

Secondary Outcomes

the association between normative diffusion value of DTI (FA and ADC value) and disease activity activity score of AAV (BVAS).

Birmingham Vasculitis Activity Score (BVAS) is a index of vasculitis disease activity, with the score range 0-63. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) are two parameters that can be read through DTI image .

Time frame: 2 years

the association between normative diffusion value of DTI (FA and ADC value) and serum biomarkers of AAV associated neuropathy

sCD163, Nfl（neurofilament light polypeptide）and OPN（osteopontin）are new biomarkers of peripheral neuropathy

Time frame: 2 years

the Application of Diffusion Tensor Imaging in the Evaluation of Peripheral Neuropathy in ANCA Associated Vasculitis

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts