Immunomodulatory Effects of Dexmedetomidine Infusion

Alexandria University100 enrolled

Overview

Anesthetic management may affect both immunostimulatory and immunosuppressive mechanisms directly by modulating immune cell function or indirectly by attenuating the stress response, Thus, the choice of anesthetic technique may affect clinical outcomes by perturbing the balance between pro- and anti-inflammatory responses,anesthetics favoring this delicate balance are thus desirable as their use may reduce postoperative complications and mortality

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Major Abdominal Surgery

Interventions

DexmedetomidineDRUG

patients will receive a loading dose of IV Dexmedetomidine1μg/kg slowly just before induction of anesthesia, then Dexmedetomidine infusion started at a rate of 0.5μg/kg/h.

0.9% sodium chlorideDRUG

patients will receive an equal volume of 0.9% sodium chloride (both the loading, and the infusion

Eligibility

Sex: ALLMin age: 25 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * scheduled for elective laparoscopic major abdominal surgeries; * ASA class II-III Exclusion Criteria: \- 1- Patients with severe infection or diseases in respiratory system 2- Patients with severe arrhythmia or bradycardia 3- Patients with severe diseases in liver, kidney, endocrine or immune system. 4- Patients with history of uncontrolled hypertension, A-V conduction block. 5- Patients who had administrated the α-adrenergic agonists or β-receptor antagonist. 6- Patients who received the chemotherapy, radiotherapy, or immunotherapy within one month before operation 7- Patients who had feverbefore operation

Locations (1)

Rehab Abd Elraof Abd Elaziz

Alexandria, Egypt

RECRUITING

Outcomes

Primary Outcomes

immune-modulatory effects

serum concentrations of C-reactive protein (CRP) level ,The pro-inflammatory cytokines interleukin (IL)-1β, and IL-6 and anti-inflammatory cytokines IL-10 will be measured at four times: T0 (before anesthesia), T1 (1 h after surgery), T2 (24 h after surgery) and T4 (72 h after surgery

Time frame: three days after surgery

Central Contacts

rehab A. Abd Elaziz, Ass. Prof.

CONTACT

01001073703 trcium2002@yahoo.com

rehab A. Abd Elaziz, Ass.Prof.

CONTACT

01001073703 trcium2002@yahoo.com

Data from ClinicalTrials.gov

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