Exercise Intervention in Liver Transplant Candidates

Aristotle University Of Thessaloniki30 enrolled

Overview

The aim of the study is to investigate the effect of personalised exercise interventions in liver transplant candidates, aiming to prevent or limit sarcopenia and frailty, as well as improving their cardiorespiratory health.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Liver Diseases

Interventions

Personalised exerciseBEHAVIORAL

Personalised exercise intervention including aerobic and resistance training

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Liver transplant candidates, accepted in the waiting list of the Surgical Department of Transplantation A.U.Th., General Hospital of Thessaloniki "Ippokratio". Exclusion Criteria: * Recent (\<12 months) Acute Myocardial Infraction * Recent (\<12 months) brain strokes * Uncontrolled and/or untreated arrythmia * Hepatic encephalopathy * Bed-bound patient * Liver Transplantation * Death

Locations (2)

Laboratory of Sports Medicine

Thermi, Thessaloniki, Greece

Surgical Department of Transplantation A.U.Th.

Thessaloniki, Thessaloniki, Greece

Outcomes

Primary Outcomes

Change from Baseline "Liver Frailty Index" value at 12 weeks

A frailty index for patients with cirrhosis, comprised of three performance-based metrics

Time frame: After 12-week exercise intervention

Change from Baseline "6 Minute Walking Test" value at 12 weeks

A walking test for patients to evaluate their functional capacity

Time frame: After 12-week exercise intervention

Secondary Outcomes

VO2max

Maximum oxygen consumption during incremental exercise

Time frame: Before intervention initiation and after 12-week exercise intervention

Data from ClinicalTrials.gov

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