The proposed study is a single-center, randomized controlled pilot trial of adults who suffer in-hospital cardiac arrests. Using cerebral oxygenation and end-tidal carbon dioxide physiological targets to predict survival and neurological outcome, the impact of physiological-feedback CPR will be assessed. 150 adult patients who have a cardiac arrest event at NYU Tisch Hospital will be randomized to one of two treatment groups: (1) Physiological-Feedback CPR or (2) Non-Physiological (Audiovisual) Feedback CPR.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Non-physiologically guided CPR using AV feedback (integrated into defibrillators)
Physiological feedback CPR using an optimal regional O2 Saturation (rSO2), End-tidal CO2 (ETCO2) or combined (rSO2/ETCO2) target
NYU Langone Health
New York, New York, United States
Rate of Return of Spontaneous Circulation (ROSC)
Time frame: Day 0
Cerebral Performance Category (CPC) Score
Total range of score is 1 (Good cerebral performance) to 5 (Brain death). The higher the score, the worse the clinical condition.
Time frame: Day 1-2
Cerebral Performance Category (CPC) Score
Total range of score is 1 (Good cerebral performance) to 5 (Brain death). The higher the score, the worse the clinical condition.
Time frame: Day 30
Change in mean rSO2 during CPR as markers of the quality of resuscitation
Time frame: Day 0
Change in mean ETCO2 during CPR as markers of the quality of resuscitation
Time frame: Day 0
Release of interleukin (IL)-6
Time frame: Day 0
Release of Lactate
Time frame: Day 0
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.