The Effects of Bifidobacterium Longum 1714® in a Population With Low Mood

Inclusion Criteria: 1. Participants must be able to give written informed consent. 2. Male or female adults aged between ≥18 to ≤70 years. 3. Participants with a BMI between ≥18.5 and ≤29.9 kg/m2. 4. Meet the DSM-5 criteria for major depressive disorder (MDD) at screening (V0) and at baseline (V1). 5. BDI-II (Beck's Depression Inventory II) total score of 14-28 (mild \[14-19\] or moderate \[20-28\] depression) at screening (V0) and at baseline (V1). 6. Be willing to maintain stable dietary habits and physical activity levels throughout the study period. 7. Be able to communicate well with the Investigator, to understand and comply with the requirements of the study and be judged suitable for the study in the opinion of the Investigator. Exclusion Criteria: 1. Participants who are at risk of suicide. 2. Recent use of dietary supplements, probiotics, or other fermented foods that contain live bacteria within last 4 weeks. 3. Participant who has been on antibiotics during the past 3 months. 4. Participant with a malignant disease or any concomitant end-state organ disease and/or laboratory abnormalities considered by Investigators to be risky or that could interfere with data collection. 5. Participant who has a significant physical illness (including IBS, does not include people with controlled hypertension or type II diabetes). 6. Participant who is severely immunocompromised (HIV positive, transplant patient, on anti-rejection medications, on a steroid for \>30 days, or chemotherapy or radiotherapy within the last year). 7. Significant psychiatric diagnosis (e.g., bipolar) other than depression. 8. Participants who are on anxiolytics, anti-depressants, antipsychotics, anticonvulsants, centrally acting corticosteroids, opioid pain relievers, hypnotics, and/or prescribed sleep medication/ herbals (e.g., valerian, St. John's Wort). 9. Participants with a current history of drug (including illicit drug) and /or alcohol abuse at the time of enrolment. 10. Participants who are pregnant (determined by urine pregnancy test for all individuals of childbearing potential at screening, regardless of contraceptive use or relationship status), breastfeeding, or wish to become pregnant during the study. 11. Participants who are suffering from post-natal depression. 12. Participants currently of childbearing potential, but not using an effective method of contraception, as outlined below: 1. Complete abstinence from intercourse two weeks prior to administration of Investigational Product, throughout the clinical trial, until the completion of follow-up procedures or for two weeks following discontinuation of the Investigational Product in cases where participant discontinues the study prematurely. (Participants utilising this method must agree to use an alternate method of contraception if they should become sexually active and will be queried on whether they have been abstinent in the preceding 2 weeks when they present to the clinic for the Final Visit). 2. Has a male sexual partner who is surgically sterilised prior to the Screening Visit and is the only male sexual partner for that participant. 3. Sexual partner(s) is/are exclusively female. 4. Use of acceptable method of contraception, such as a spermicide, mechanical barrier (e.g., male condom, female diaphragm) or contraceptive pill. The participant must be using this method for at least 2 weeks prior to use of the Investigational Product and at least 1 week following the end of the study. 5. Use of any non-hormonal intrauterine device (IUD) or contraceptive implant with published data showing that the highest expected failure rate is less than 1 % per year. The participant must have the device inserted at least 2 weeks prior to the first Screening Visit, throughout the study, and 2 weeks following the end of the study. 13. Known allergy to any of the components of the test product. 14. Participation in a clinical study with an Investigational Product within 60 days before screening or plans to participate in another study during the study period. 15. Participant has a history of non-compliance or in the opinion of physician deemed unsuitable to participate in the study.