Study on Serum Cystatin C and PET-DAT in Patients With Parkinson's Disease

Second Affiliated Hospital, School of Medicine, Zhejiang University121 enrolled

Overview

To investigate the relationship between serum cystatin C and dopamine receptor(DAT) loss in patients with parkinson's disease(PD)

Number of people suffered from Parkinson disease (PD) is increasing every year. PET imaging of dopamine transport receptors（DAT） serves as the gold standard for the diagnosis and monitoring of PD development. However, due to high costs and radiation reasons, it is not suitable for long-term follow-up. Serum cystatin C can be easily obtained and cheap as an indicator. In recent years, studies have gradually found that it is related to the progression of H\&Y staging of Parkinson's disease. To this extent, we want to further explore whether it can reflect the loss of DAT in the brain. Explore whether it can partially replace the role of DAT imaging for future clinical evaluation.

Study Type

OBSERVATIONAL

Enrollment

121

Conditions

Parkinson's Disease

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged between 20 and 80 years and whose laboratory results included the levels of serum Cystatin C within a month from the PET-DAT were recruited. Exclusion Criteria: * To make the study cohort more homogeneous, PD patients with either a long-standing duration (≥5 years) or advanced Hoehn and Yahr (H\&Y) staging (≥3) were excluded.

Locations (1)

Second Affiliated Hospital, College of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Cystatin C assesses the loss of dopaminergic neurons

Explore whether Cystatin C can respond to the loss of dopaminergic neurons

Time frame: through study completion, an average of 1 year

Central Contacts

BaoRong Zhang, MD

CONTACT

13958167260 brzhang@zju.edu.cn

Data from ClinicalTrials.gov

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