Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension

Inclusion Criteria: * Any sex. * That they agree to participate in the study and give their informed consent in writing. * Age between 18 and 65 years old at the beginning of the study. * Patients with essential arterial hypertension with BP ≥140 / 90 mmHg and \<180/110 mmHg. * Women of childbearing potential using a contraceptive method (barrier, oral hormonal, injectable, subdermal), menopausal or surgically sterile. Exclusion Criteria: * The drug is contraindicated for medical reasons. * Glomerular filtration rate ≤30 ml / min x 1.73 m2. * Hypersensitivity to any of the components of the formula or other sulfonamides. * Patients treated with other diuretics. * Patient with a history of vascular disease (cerebrovascular disease, acute coronary syndrome, etc.) and acute renal failure in the last 6 months. * Patient with severe complications of type 2 diabetes mellitus (Ketoacidosis or hyperosmolar nonketotic coma). * Patients participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks. * Positive pregnancy test, women who are pregnant, breastfeeding or planning a pregnancy while conducting the study. * Oncological patients (except basal cell skin cancer) or with serious diseases that, in the opinion of the investigator, have a serious prognosis or a life expectancy of less than 1 year, as well as mental illnesses. * Patients diagnosed with gout. * Patients whose participation in the study may be influenced (employment relationship with the research center or sponsor, inmates, etc.).