Differential Adaptation of Renal Function in Intense Physical Exercise

Hospital Clínico Universitario de Valladolid40 enrolled

Overview

In recent years there has been a significant increase in the number of participants in high intensity and duration sports events. This type of physical exercise has been reported to lead to an apparently transitory deterioration in kidney function. The injury mechanisms involved in this process have not been fully studied, but several have been proposed as potential causes, such as tissue ischemia, disruption of the permeability of the glomerular basement membrane, damage to the ultra-structure of skeletal muscle, structural involvement of the renal parenchyma, exercise-associated hyperthermia or insufficient hydration during exercise. Urinary biomarkers, which are a more precise tool than serum creatinine when it comes to detecting subclinical kidney damage, may be key to elucidate the characteristics of exercise-related kidney injury. The aim of this study is to carry out an integrative analysis of the development of exercise-associated subclinical acute kidney injury.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Acute Kidney Injury

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years. * Able to understand the objectives of the study and to provide informed consent. * Body mass index between 18.5 and 29.9 kg / m2 * Active sportsman/woman (defined as previous experience with the planned tests and performing vigorous-intensity aerobic activity at least three times per week). Exclusion Criteria: * History of chronic kidney disease, hypertension, uncontrolled diabetes (defined as fasting glucose levels ≥200 mg/dl or HbA1c ≥9%), peripheral vascular disease, heart disease, neurological disease or thyroid disease. * Use of NSAIDs in the 72h prior to the test. * Consumption of statins or anabolic steroids. * Some kind of major physical injury in the four months prior to the tests.

Outcomes

Primary Outcomes

Absolute change in urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels

Time frame: 24 hours

Absolute change in urinary Kidney Injury Molecule-1 (KIM-1) levels

Time frame: 24 hours

Secondary Outcomes

Absolute change in serum creatinine levels

Time frame: 24 hours

Absolute change in proteinuria

Time frame: 24 hours

Differential Adaptation of Renal Function in Intense Physical Exercise

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes