The Effect of Respiratory Muscle Training for Patients With COPD and Mild Cognitive Impairment

Taichung Veterans General Hospital70 enrolled

Overview

Patients with COPD and MCI received either inspiratory muscle training or inspiratory plus expiratory muscle training and compared the therapeutic effects

Patients with COPD and MCI were recruited, and were randomly assigned to the experimental group and the control group. The experimental group consisted of EMT and IMT for a total of 8 weeks, while the control group received IMT only. Outcomes measured and compared in this cohort were diaphragmatic thickness fraction and excursion examined by ultrasound, the dyspnea score of modified Medical Research Council (mMRC), the cognitive score of Mini-Mental State Examination (MMSE), and the score of COPD Assessment Test (CAT). In addition, the pulmonary function test, the cardiopulmonary exercise test, and the physiology performance of six minute walking test were also obtained. We also analyzed the difference of each parameters before and after training in each patient.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease Mild Cognitive Impairment

Interventions

Respiratory muscle trainingBEHAVIORAL

Inspiratory and expiratory muscle training were performed using a breathing trainer (Dofin DT11/14, Galemed Co. Ltd, Taiwan) for 30 minutes a day with a total of eight weeks. Before the training, the MIP and maximal expiratory pressure (MEP) were documented by the best performance of three trials with a digital pressure gauge (GB60, Jitto International Co. Ltd, Taiwan)

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. Having definite diagnosis of COPD, namely the value of the FEV1 divided by forced vital capacity (FVC) 10 to 15 minutes after beta-2 agonist inhalation being less than 0.7. * 2\. The score of Mini-Mental State Examination (MMSE) being between 23 and 27 Exclusion Criteria: * 1\. Being not able to follow instructions on respiratory muscle training or complete the questionnaires of our study due to cognitive impairment. * 2\. Having difficulty to complete the cardiopulmonary exercise testing or the six minute walking test (6MWT) due to high risk cardiopulmonary diseases or other orthopedic conditions. * 3\. Having the diagnosis of lung cancer or history of receiving thoracoabdominal surgery * 4\. Having Body Mass Index more than 30

Locations (1)

Taichung Veterans General Hospital

Taichung, Taiwan

Outcomes

Primary Outcomes

MMSE

Mini-Mental State Examination

Time frame: 8 weeks

Secondary Outcomes

Diaphragmatic thickness fraction

Diaphragmatic thickness fraction on ultrasonography

Time frame: 8 weeks

chronic obstructive pulmonary disease assessment test (CAT)

questionnaire of dyspnea

Time frame: 8 weeks

diffusing capacity of the lung for carbon monoxide (DLCO)

diffusing capacity of the lung for carbon monoxide (DLCO) in pulmonary function test

Time frame: 8 weeks

dead space fraction (Vd/Vt)

dead space fraction (Vd/Vt) in cardiopulmonary function test

Time frame: 8 weeks

the distance walked in 6 minutes

Time frame: 8 weeks

Diaphragmatic excursion

Diaphragmatic excursion on ultrasonography

Time frame: 8 weeks

forced vital capacity

forced vital capacity tested in pulmonary function test

Time frame: 8 weeks

forced expiratory volume in 1 second

forced expiratory volume in 1 second in pulmonary function test

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.