High Dose Omeprazole in Patients With Pancreatic Cancer

Inclusion Criteria: * Newly diagnosed exocrine pancreatic cancer with either pathology, histology, or radiology imaging documented as adenocarcinoma * Patient is a candidate for surgical resection of pancreatic cancer * ≥ 18 years old at the time of informed consent * ECOG Performance Status 0-2 * Patients with or without neoadjuvant chemotherapy will be eligible * Ability to provide written informed consent and HIPAA authorization * Women of childbearing potential definition must have a negative pregnancy test within 14 days of registration. All women (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) are considered to have childbearing potential unless they meet one of the following criteria: * Prior hysterectomy or bilateral oophorectomy; * Has not had menses at any time in the preceding 24 consecutive months * Candidate for surgery per standard of care of per surgeon's discretion Exclusion Criteria: * Patients with pancreatic malignant tumor histologically confirmed as neuroendocrine or any other type of malignancies * Positive pregnancy test, pregnant, or breastfeeding * Known hypersensitivity to any component of the formulation or substituted benzimidazoles * Any other clinically significant laboratory abnormality that would compromise patient safety or the outcome of the study * Any clinically significant and/or uncontrolled cardiac-related abnormality that would compromise patient safety or the outcome of the study * Medical condition that might affect the absorption of study medications in the opinion of the investigator.