Stroke has the characteristics of high morbidity, disability and fatality rate, which brings heavy spiritual and economic burdens to the family, society and the country. In my country, 33%-50% of ischemic strokes are attributed to intracranial atherosclerosis. Studies have shown that oxidative stress, increased blood viscosity, and damage to vascular endothelial cells are important mechanisms for the development of cerebral infarction. Salvia miltiorrhiza is a commonly used traditional Chinese medicine in traditional medicine in my country. Salvia miltiorrhiza polyphenolic acid is the effective ingredient of salvia miltiorrhiza. It is the water-soluble active part of salvia miltiorrhiza. It can resist oxidation, anticoagulation, antiplatelet, cell protection, and expand blood vessels, thereby achieving protection Cardiovascular system. The purpose of this study was to evaluate the effects and adverse effects of salvianolic acid on acute ischemic stroke onset within 72 hours, and to evaluate the improvement of patients' ischemic area perfusion and clinical function scores.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
1
salvianolic acid, injection, 100mg+0.9%NaCl 250ml, qd, 14 days
0.9% NaCl
Dai Haibin
Hangzhou, Zhejiang, China
MRS score
MRS score ≤2
Time frame: 90 days
Cerebral blood flow volume (CBV)
Cerebral blood flow volume
Time frame: 90 days
Cerebral blood flow (CBF)
Cerebral blood flow
Time frame: 90 days
NIHSS score
NIHSS score
Time frame: 90 days
Adverse drug reactions (ADR)
Adverse drug reactions
Time frame: 90 days
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