Resting Heart Rate Monitoring for Optimized Treatment and Surveillance of Hyperthyroidism

University Hospital, Basel, Switzerland35 enrolled

Overview

The investigators want to investigate if a continuous heart rate monitoring with a wrist worn fitnesstracker can be useful in the treatment and surveillance of patients suffering from Graves' disease.The aim of our research project is two-fold: First, to evaluate the use of continuous heart rate monitoring as a potential substitute for hormone measurements during treatment of hyperthyroidism. Second, to use continuous heart rate monitoring as a tool for early detection of relapse after discontinuation of antithyroid drugs.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hyperthyroidism Graves Disease

Interventions

Continuous heart rate monitoringDIAGNOSTIC_TEST

Continuous heart rate monitoring with a wrist worn fitnesstracker

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: All participants: * BMI 17 to 35 kg/m2 * Diagnosis of Graves' disease (matching one of the following criteria: elevated TRAb and/or ultrasonography and functional imaging consistent with Graves' disease) * In possession of a smart phone * Able to use a wearable device and willing to regularly upload their biometric data * Informed consent as documented by signature (Appendix Informed Consent Form) Group "treatment": * TSH \< 0.2 mIU/l and * fT4 \> 25 pM or fT3 \> 8 pM * ATD planned, additional treatment with propranolol allowed Group "surveillance": * TSH within the reference range between 0.3 and 4.5 mlU/l * Cessation of ATD is planned within the next 2-4 weeks Exclusion Criteria: * Chronic treatment with beta blocker or verapamil-type calcium antagonist for other reason than symptomatic treatment of hyperthyroidism (propranolol) * Treatment with amiodarone * Pacemaker with continuous stimulation. * Severe concomitant diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer * Abuse of alcohol or illicit drugs * Allergic to nickel or silicone * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

Outcomes

Primary Outcomes

resting heart rate

continuous resting heart rate measurement with fitnesstracker in relation to the thyroid hormone levels in patients during and after treatment with anti-thyroid drugs.

Time frame: four months