The aim of this study is to compare the effect of tropicamide 0.5% and tropicamide 1% on intraocular pressure and anterior chamber parameters in patients with Diabetes Mellitus.
Patients with diabetes type 1 and type 2 older than 21 years of age, in the specialized clinic of Kowsar Hospital (Semnan University of Medical Sciences) are examined. Eligible individuals enter the study and are randomly assigned to group 1 or group 2. In each group, visual acuity measurement, slit lamp biomicroscopy and fundus examination are performed. Intraocular pressure is measured with Goldmann applanation tonometer. pupil size, refraction and keratometry are measured with two different autorefractokeratometers. keratometry, pupil size and other anterior chamber parameters are also evaluated by Oculus Pentacam imaging. Then, the patients receive tropicamide 0.5% drops in group 1 and tropicamide 1% drops in group 2. 30 minutes later, all previous measurements are repeated. Patients and the ophthalmologist and the data analyzer are unaware of the drug type.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
98
Tropicamide eye drops are used for dilating pupils (mydriasis) to do comprehensive fundus examination.
Kowsar Semnan Research and Medical Training Center
Semnan, Iran
Change from baseline in Intraocular pressure (IOP)
The intraocular pressure is measured by Goldmann applanation tonometry
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in pupillary diameter
The diameter of the participants' pupil is measured by Scheimpflug camera (Oculus Pentacam); Autorefractokeratometer (TOMEY RC-5000 and Topcon KR-1)
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in Keratometry
The keratometry is obtained by Scheimpflug camera (Oculus Pentacam); Autorefractokeratometer (TOMEY RC-5000 and Topcon KR-1)
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in anterior chamber depth (ACD)
The ACD is measured by Scheimpflug camera (Oculus Pentacam)
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in anterior chamber volume (ACV)
The ACV is measured by Scheimpflug camera (Oculus Pentacam)
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in anterior chamber angle (ACA)
The ACA is measured by Scheimpflug camera (Oculus Pentacam)
Time frame: Before intervention, 30 minutes after intervention
Change from baseline in central corneal thickness (CCT)
The CCT is measured by Scheimpflug camera (Oculus Pentacam)
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Time frame: Before intervention, 30 minutes after intervention