Comparison of Genomic and Transcriptomic Patterns Between CTC and Metastatic Tumormetastatic Tumor

Samsung Medical Center20 enrolled

Overview

This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

NSCLC Stage IV NSCLC Stage IIIB

Interventions

cohort studyDIAGNOSTIC_TEST

no intervention

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * All subjects need to sign the informed consent form * All subjects have non-small cell lung cancer which suspected on chest CT or confirmed pathologically preoperatively * Treatment naïve advanced lung cancer (including extensive stage IIIb and stage IV) * Patients who were suitable to provide enough metastatic tumor tissue and blood (30ml) for the single cells sequencing Exclusion Criteria: * Patients with previous history of lung cancer * Have been undergone chemotherapy or radiotherapy due to non-small call lung cancer * Have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix within 5 years before enrollment

Locations (1)

Samsung Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

The gene expression and the cell population

Methods for the single cell RNA sequencing and whole exome sequencing of the tumor cells With the tissue biopsied specimens, scRNAseq (by 10X Genomics platform) and whole exome seq will be carried out.

Time frame: 3 year

Data from ClinicalTrials.gov

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