This is a hospital-based retrospective cohort study and the Immunohematologic characteristics of COVID-19 patients will be investigated systematically.
This is a hospital-based retrospective cohort study and the Immunohematologic characteristics of COVID-19 patients will be investigated systematically. In this study, we will seek to understand the association between SARS-CoV-2 infection and blood groups and explore the Anti-A and Anti-B effects in COVID-19 patients with graded severity. We will analyze the transfusion requirement and the clinical recurrences of COVID-19 patients. The discrepancy of blood group phenotypes in COVID-19 patients with graded severity will be also analyzed on the molecular level. This retrospective cohort study was conducted using electronic health recording data in Tongji Hospital. The clinical characteristics for all eligible patients will be retrieved. The records will be verified to avoid possible bias. Data collection was carried out independently by two investigators and reviewed by two different investigators.
Study Type
OBSERVATIONAL
Enrollment
2,000
Tongji Hospital
Wuhan, Hubei, China
RECRUITINGABO and Rh distribution
ABO and Rh phenotype distribution refers to the phenotype frequency of the ABO and Rh subtypes in severe and non-severe COVID-19 patients
Time frame: 1 year
ABO antibody titers
ABO antibody titers refers to both anti-A and anti-B antibodies in severe and non-severe COVID-19 patients
Time frame: 1 year
Transfusion incidence
Transfusion incidence refers to the number of COVID-19 hospitalized patients who received transfusion
Time frame: 1 year
Patients with coagulopathy
Patients with coagulopathy refers to patients hospitalized with Covid-19 to develop coagulopathy
Time frame: 1 year
Leukocyte and neutrophil counts
Leukocyte and neutrophil counts refer to the number of Leukocyte and neutrophil COVID-19 hospitalized patients with graded severity
Time frame: 1 year
outcomes of SARS-CoV-2 infection
outcomes of SARS-CoV-2 infection refer to the intubation and death in SARS-CoV-2 infected patients
Time frame: 1 year
Polymorphism of ABO blood group
Polymorphism of ABO blood group refers to the variations and alleles of the ABO gene in COVID-19 patients
Time frame: 1 year
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