LPN in Patients With High-complex Renal Tumors

Samsun Liv Hospital78 enrolled

Overview

The study aims to investigate the rationale for LPN in patients with high-complexity renal tumors in terms of oncologic and functional outcomes.

From November 2009 to October 2018, 399 patients underwent LPN and 307 patients to laparoscopic radical nephrectomy (LRN). 41 patients with RENAL score ≥ 10 enrolled in LPN and 265 patients to the LRN group. Propensity score matching (matched by age, gender, clinical tumor stage, tumor size, baseline renal function, comorbidities such as diabetes mellitus (DM), hypertension (HT), coronary artery disease (CAD), and final tumor pathology of RCC) was used to reduce selection bias. Functional and oncological outcomes were compared between the two groups. After propensity score analysis, 39 patients in the LRN group were matched with 39 in the LPN group.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Renal Cancer Renal Neoplasm Renal Cell Carcinoma Surgery Oncology Kidney Ischemia Kidney Injury Urologic Neoplasms Urologic Cancer Kidney Neoplasms

Interventions

laparoscopic partial nephrectomyPROCEDURE

Nephron sparing minimally invasive surgery

Laparoscopic radical nephrectomyPROCEDURE

Completely removal of kidney by using laparoscopic surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with complete data * Patients with single renal tumor on the effected side * Patients who approved the written consent form Exclusion Criteria: * Patients who not approved the written consent form * Patients with incomplete data * Patients with low or mild complexity renal tumors

Locations (1)

Ondokuz Mayıs University, Department of Urology

Samsun, Turkey (Türkiye)

Outcomes

Primary Outcomes

Operation time

time from onset to complete of surgery

Time frame: at the end of the surgery

Blood loss

amount of bleeding during surgery (mL)

Time frame: at the end of the surgery

warm ischemia time

The clamp time of the renal artery and vein which is required to complete tumor excision and renorrhaphy

Time frame: at the and of the surgery

Postoperative complication

abnormal problmes that may be seen after surgery and require additional intervention, treatment or follow-up

Time frame: up to 3 months postoperatively

functional outcomes

serum creatinine level (mg /dL) and estimated glomerular filtration rate (CKD Epidemiology Collaboration (CKD-EPI) equation) (mL/min/1.73 m2)

Time frame: 1 year after the surgery

surigcal margin status

presence or absence of tumors at the surgical margin

Time frame: postoperative follow-up, through study completion, an average of 1 year

CKD stage upgrading

evaluation of preoperative and postoperative renal functions according to chronic kidney disease stages

Time frame: postoperative follow-up, through study completion, an average of 1 year

Oncological outomes

Presence or absence of local and/or distal tumor recurrence

Time frame: postoperative follow-up, through study completion, an average of 1 year

Data from ClinicalTrials.gov

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