According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
136
1 Hz rTMS
Sorbonne University, Pitié-Salpêtrière Hospital
Paris, France
RECRUITINGCentre Hospitalier Henri Laborit
Poitiers, France
RECRUITINGYale Brown Obsessive Compulsive Scale score
Significant clinical change (≥ 25%) from baseline to two weeks after the treatment sequence, assessed by a significant reduction in YBOCS scores at day 25
Time frame: baseline and 25 days
Yale Brown Obsessive Compulsive Scale
Significant clinical change of the YBOCS score (≥25% decrease), from baseline to day 70
Time frame: baseline and 70 days
general assessement functioning (GAF)
Change of the general assessement functioning (GAF) at day 25
Time frame: baseline and 25 days
general assessement functioning (GAF)
Change of the general assessement functioning (GAF) at day 70
Time frame: baseline and 70 days
Clinical Global Impression (CGI)
Clinical Global Impressions (CGI) change at day 25
Time frame: baseline and 25 days
Clinical Global Impression (CGI)
Clinical Global Impressions (CGI) change at day 70
Time frame: baseline and 70 days
Adverse events linked to the rTMS treatment
Number and types of adverse events linked to the rTMS treatment
Time frame: 70 days
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