Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation

Heidelberg University50 enrolled

Overview

The induction of anesthesia is one of the most critical situations for high-risk-patients undergoing major surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase. This observational study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of antihypotensive drugs during the induction and the surgical procedure in heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Blood Pressure, Low

Interventions

EtomidateDRUG

Use of etomidate during induction as decided by attending anesthesiologist

MidazolamDRUG

Use of midazolam during induction as decided by attending anesthesiologist

SevofluraneDRUG

Use of sevoflurane during induction as decided by attending anesthesiologist

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Heart failure patients scheduled for implantation of left ventricular assist device (LVAD) Exclusion Criteria: * Pregnancy * Presence of another cardiac assist device in the patient (for example ECLS) * No consent of the patient

Outcomes

Primary Outcomes

Post-Induction hypotension

The incidence of hypotension in the first 30 minutes after the induction of anesthesia

Time frame: First 30 minutes after induction of anesthesia

Secondary Outcomes

Antihypotensive drugs after induction

Use of antihypotensive drugs during the first 30 minutes after induction of anesthesia

Time frame: First 30 minutes after induction of anesthesia

Antihypotensive drugs during the procedure

Use of antihypotensive drugs during the procedure

Time frame: Begin of the procedure until end of the procedure

Length of stay on the intensive care unit (ICU)

The time the patient has to be treated on intensive care unit after the procedure (in hours) before submission.

Time frame: After the procedure and transport to intensive care unit, total time in hours until submission from I. Expected time frame is 48 to 96 hours.CU

Delirium

Diagnosis of postoperative delirium

Time frame: First 24 hours after the end of the procedure

Kidney

Occurrence of acute kidney failure as defined by Kidney Disease: Improving Global Outcomes (KDIGO)

Time frame: First 28 days after procedure

Mortality

Mortalitiy in the first 28 days after the procedure

Time frame: First 28 days after procedure

Central Contacts

Adrian E Stephan, MD

CONTACT

004962215636107 adrian.stephan@med.uni-heidelberg.de

Data from ClinicalTrials.gov

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