Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants

King's College London30 enrolled

Overview

To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Bronchopulmonary Dysplasia

Interventions

Calculation of ventilation-perfusion ratioOTHER

Three to five paired measurements of fraction of inspired oxygen and peripheral oxygen saturations. Insertion of mainstream capnograph with combined pressure and flow sensor to perform end-tidal capnography measurement. Echocardiogram to assess intra-cardiac shunting.

Eligibility

Sex: ALLMin age: 22 WeeksMax age: 28 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: \- Exclusion Criteria: * Congenital or chromosomal anomalies

Locations (1)

King's College Hospital NHS Foundation Trust

London, United Kingdom

Outcomes

Primary Outcomes

Calculation of the alveolar surface area in prematurely born infants using validated functional morphometry

Time frame: One year

Data from ClinicalTrials.gov

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