Ursodeoxycholic Acid (Udca) as a Local Drug Delivery Agent in the Treatment of Intra-bony Defects

SVS Institute of Dental Sciences26 enrolled

Overview

The aim of this study is to evaluate the efficacy of ursodeoxycholic acid as local drug delivery agent in intra- bony defect to achieve bone regeneration.

Experimental: Main treatment group the prepared UDCA gel will be injected using a syringe with blunt cannula into the defect site. Comparator: In patients allocated to control group, placebo gel will be injected in to the defect site using a syringe with blunt cannula.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Bone Regeneration

Interventions

Ursodeoxycholic acid gelDRUG

Following scaling and root planing in intrabony defects UDCA gel will be injected

Eligibility

Sex: ALLMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Systemically healthy male and female patients of age\>18 years with intrabony defects - two wall or three wall defects and probing pocket depths (PPD) of \>3mm will be included Exclusion Criteria: * Medically compromised patients, pregnant women, heavy smokers, and patients who underwent radiotherapy or chemotherapy will be excluded.

Locations (1)

SVS Institute of Dental Sciences

Hyderabad, Telangana, India

RECRUITING

Outcomes

Primary Outcomes

Evaluation of bone regeneration

Radiovisiography (RVG) will be used to assess bone regeneration achieved post-operatively after 3 months and 6 months.