As COVID-19 pandemic is still ongoing, patients follow-up begins to reveal cognitive and psychological disorders. There are not yet well described, neither their physiopathology. This study will consist in the detection and characterization of cognitive and psychological impairments in young patients under 65 years of age who have been hospitalized more than 72 hours for a severe COVID-19 infection.
Initial consecutive screening of patients (\<65 years) hospitalized between the 01/10/2020 and the 01/07/2021 for more than 72 hours for COVID-19 infection in 6 hospitals of the East of France. If detection of cognitive complaints (QPC scale : Questionnaire of cognitive complaints), continuation of the study. Evaluation with cognitive assessments, morphological and functional imaging and EEG will be done at 9 ± 3 months and 2 years after initial hospitalisation. Data will be collected concerning social and professional outcome. An ancillary study will be conducted at the Nancy University Hospital. This ancillary study is entitled "TRAUMA-COV: Screening and therapeutic proposal of post-traumatic sequelae in the aftermath of a severe Covid-19 in young subjects". The main objective of this study is to evaluate the incidence of post-Covid-19 post-traumatic disorders (post-traumatic stress disorder, psychogenic and somatoform dissociative tendency, neurological dissociative disorder) in a longitudinal way. This optional study will be offered to all patients from the main study who meet the selection criteria.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
76
Complete cognitive and psychological assessment
Brain MRI Optional: Brain FDG PET (Brain positron emission tomography with F-18 fluorodeoxyglucose)
Electroencephalogram (EEG) Optional: polysomnography, lumbar puncture
Nancy University Hospital, Department of Neurology
Nancy, France
Characterization of cognitive and psychological disorders 1 year after COVID-19 infection
Perfomance to cognitive assessment
Time frame: up to 1 year
Frequency of cognitive and psychological disorders 1 year and 2 years after COVID-19 infection
Number of patients with confirmed cognitive and/or psychological disorder compared to the total number of patients who completed the QPC scale
Time frame: up to 2 years
Severity of cognitive and psychological disorders 1 year after COVID-19 infection
Perfomance to cognitive assessment
Time frame: up to 1 year
Evaluate the prognosis of cognitive and psychological disorders at 2 years according to the proposed medical care
Cognitive assessment
Time frame: up to 2 years
Evaluate the prognosis of cognitive and psychological disorders at 2 years according to the proposed medical care
Change from baseline in professional status
Time frame: up to 2 years
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Psychiatric consultation if necessary
Psychiatric consultation if necessary (before the end of their participation in the study)