Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction

Central Hospital, Nancy, France34 enrolled

Overview

The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and correlate the presence of the virus in the urine with proximal tubular dysfunction (defined by the association of at least 2 abnormalities: tubular proteinuria, renal phosphate leak, uricosuria, normoglycemic glycosuria, amino aciduria)

Study Type

OBSERVATIONAL

Enrollment

Conditions

SARS-CoV2 Infection Proximal Tubule Dysfunction

Interventions

RT-PCR SARS-COV2 in urineOTHER

proteinuria/renal phosphate leak/uricosuria/glycosuria/ aminoaciduria)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Person and / or trustworthy person who has received complete information on the organization of the research and who has not opposed their participation and the use of their data * Hospitalized for ≥ 48 hours and ≤ 10 days * SARS-CoV-2 positive nasopharyngeal sample * Severity criteria: Lung involvement described as compatible with SARS-CoV-2 on radiography or scanner and partial pressure of oxygne (PaO2) / Fraction of inspired oxygen (FiO2) ≤ 300 mmHg and / or respiratory rate (RR) ≥ 30 / min Exclusion Criteria: * Known chronic kidney disease, or initial Glomerular Filtration Rate (GFR) \<60 ml / min / 1.73m2 or Renal Transplant * Known proteinuria * Known proximal tubulopathy * Treatment with Forxiga

Locations (1)

Chru Brabois

Nancy, France

RECRUITING

Outcomes

Primary Outcomes

SARS-CoV 2 viruria and its correlation with proximal tubule dysfunction

Is the detection of viral particles in urine associated with proximal tubule dysfunction, defined by two or more of the following : proteinuria, phosphate leak, aminoaciduria, hyperuricuria, and/or glycosuria

Time frame: During the first 10 days of hospitalization

Secondary Outcomes

Capacity of infection of urine viral particles

Study of the capacity for cell infection in vitro by viral particles detected in urine.

Time frame: During the first 10 days of hospitalization

Sequencing viral particles to identify possible compartmentalization of the virus

Study by sequencing of the compartmentalization of urinary and nasopharyngeal variants of SARS-CoV-2 in patients with positive urine for SARS-CoV-2.

Time frame: During the first 10 days of hospitalization

Central Contacts

Raphaël Kormann

CONTACT

+33383155533 r.kormann@chru-nancy.fr

Data from ClinicalTrials.gov

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