Safety and Efficacy of Drug-Coated Balloon for De-novo Lesions in Patients With Acute Coronary Syndromes (DCB-ACS)

Inclusion Criteria: 1. Age≥18 Years and \<80 years; 2. ACS patients eligible for percutaneous coronary intervention; 3. Successful preparation is defined as ≤ 30% residual stenosis with Thrombolysis in Myocardial Infarction (TIMI) Grade III flow and not evidence of type C-F dissection; 4. Vessel diameter from 2.25mm-4.0 mm ; 5. Lesion length ≤ 28 mm; 6. A single culprit lesion or 1 lesion in each of two vessels ; 7. Eligible for enrollment and provide written informed consent. Exclusion Criteria: Clinical Exclusion Criteria： 1. Stable angina or asymptomatic myocardial ischemia; 2. Cardiogenic shock or requiring mechanical support for breathing and circulation; 3. Hemodynamically unstable tachyarrhythmia or bradyarrhythmia; 4. Plan to perform cardiac surgery or non-cardiac surgery within 24 months of percutaneous coronary intervention; 5. A history of stroke within 6 months; 6. History of severe renal insufficiency; 7. Life expectancy \< 12 months; 8. Pregnant women; 9. Allergies to aspirin, clopidogrel, ticagrelor, heparin, contrast agents, and paclitaxel, patients with systemic lupus erythematosus or other systemic immune diseases; 10. Patients not suitable for enrollment considered by researcher; 11. Currently participating in another trial before reaching the primary endpoint; 12. Inability to provide informed consent. Image Exclusion Criteria 1\. Chronic total occlusion (CTO); 2. Left main lesion; 3. Bifurcation lesions treated with double stents; 4. Moderate to severe distortion, angulation or severe calcification lesions; 5. Coronary artery graft stenosis; 6. In-stent restenosis; 7. To be re-hospitalized for the other scheduled PCI treatment; 8. Myocardial bridge at the target lesion.