Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF

Second Affiliated Hospital, School of Medicine, Zhejiang University40 enrolled

Overview

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH). 1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors. 2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry

Study Type

OBSERVATIONAL

Enrollment

Conditions

Subarachnoid Hemorrhage, Aneurysmal

Interventions

Lumbar punctureDIAGNOSTIC_TEST

Lumbar puncture to obtain the cerebrospinal fluid and for diagnostic test

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * SAH patients with modified Fisher Scale 3-4. Exclusion Criteria: * Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study

Locations (1)

Second affiliated hosipital of zhejiang univerisity school of medicine

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Length of hospital stay

Time frame: evaluated 1day after discharge

modified Rankin Scale

modified Rankin Scale (mRS) at discharge. mRS ranging from 0-5, higher represents worse

Time frame: evaluated 1day after discharge

Glasgow Outcome Scale

Glasgow Outcome Scale (GOS) at discharge, GOS ranging from 0-5, higher represents better

Time frame: evaluated 1day after discharge

Data from ClinicalTrials.gov

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