Non-risk Based Lang Cancer Screening With a One-off LDCT

The First Affiliated Hospital of Guangzhou Medical University11,000 enrolled

Overview

Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021.The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC.

Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021. Follow-up for post-screening management and survival was recorded. The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC. Additionally, we compared the detection rates of LC and the proportion of stage I LC cases between "high-risk" and "non-high-risk" groups according to the National Comprehensive Cancer Network (NCCN) guidelines and Chinese guideline.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

11,000

Conditions

Lung Cancer

Interventions

Low-dose computed tomographyDEVICE

The Low-dose computed tomography is conducted according to the guideline suggested by American College of Radiology.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 74 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Minimum age of 40 years among the residents in Guangzhou Exclusion Criteria: * Persons who had a diagnosis or treatment related to LC within the past 5 years, had undergone chest CT within the past year, or had significant cancer-related symptoms (e.g., hemoptysis, dyspnea, inability to climb two flights of stairs).

Locations (1)

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

The detection rate of lung cancer

Lung cancer detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases.

Time frame: 11 years

To investigate the various factors associated with the development of lung cancer

Time frame: 11 years

Secondary Outcomes

Detection rates of lung cancer and the proportion of stage I lung cancer cases between "high-risk" and "non-high-risk" groups

The detection rate of lung cancer among people with "high-risk" and "non-high-risk"factors

Time frame: 11 years

Cost-effectiveness ratio (costs of examinations, diagnoses, and treatments)

Time frame: 11 years

Central Contacts

Wenhua Liang, MD

CONTACT

+86-02-83062808 liangwh1987@163.com

Data from ClinicalTrials.gov

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