Timing of Revascularization in Patients With Diabetic Foot Ulcer and Non-critical Peripheral Artery Disease

Inclusion Criteria: * Informed consent as documented by signature * Patients that are at least 18 years old * Patients that have at least one DFU(s) of ≥ 0.2 cm2 and ≤ 10 cm2 as assessed by the ruler method multiplying the greatest length and width of the ulcer after debridement to determine the surface area. The largest eligible ulcer (≤ 10 cm2) will be defined as index ulcer and the corresponding extremity as index limb (in case of multiple equally sized ulcers the following rules will apply: If on different feet, the dominant side and if on the same foot, the more peripheral one will be the index ulcer) * Patients that have non-critical LEAD of the index leg, defined by a single non-invasive examination at screening: * Ankle brachial index (ABI) ≥ 0.5 and ≤ 0.9 AND absolute ankle pressure ≥ 50 mmHg OR * ABI \> 0.9 OR incompressible ankle pressures AND toe brachial index (TBI) ≤ 0.7 AND absolute toe pressure ≥ 30 mmHg * Patients on medical treatment for glycemic control with diagnosis of diabetes mellitus that was assessed by criteria as recommended by the guideline 2019 "ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD". Or patient without medical treatment but diagnosed with diabetes mellitus via HbA1c. * Patients with life expectancy \> 12 months and without any disabilities due to end-stage cancer, heart failure, severe chronic obstructive pulmonary disease (COPD), or dementia Exclusion Criteria: * Critical limb ischemia of the index leg defined as ABI ≤ 0.4 (or absolute ankle pressure \< 50 mmHg) * No option to assess for toe pressure due to any reason at baseline if ABI \> 0.9 or incompressible ankle pressures and patient inclusion is based on the toe pressure criteria. * Need for major amputation * Severe infection at the index foot according to IDSA classification * Patient refuses minor amputation despite strong recommendation due to severe infection, necrosis or osteomyelitis at screening assessment * Any revascularization procedure at the index leg within 3 months before randomization * Positive urine or blood pregnancy test result, breast feeding or intention to become pregnant * Non-compliance for any reason to procedures or study assessments (e.g. due to cognitive impairment or geographic distance) * Participation in another drug study within the 30 days preceding or during the present study * Untreated known antiphospholipid antibody syndrome and polycythaemia vera * Known significant bleeding risk, or known coagulation disorder (INR \> 3.0 and platelet count \< 30,000/mm3) without any option to correct within 7 calendar days after initial wound assessment