Immunomodulation Using VB-201 to Reduce Arterial Inflammation in Treated HIV - VITAL HIV Trial

Inclusion Criteria: * Documented HIV infection * On continuous antiretroviral therapy and virologically suppressed HIV infection for ≥12 weeks prior to study entry * CD4 T-cell count \> 350 cells/mm3 * Male or female between the ages ≥ 40 years of age to \<≤75 * Documented cardiovascular disease (1. Prior myocardial infarction, 2. History of percutaneous coronary intervention, 3. History of coronary artery bypass graft OR 4. Angiographic evidence of \>50% stenosis in at least one coronary artery\] OR 1 CVD risk factor (T2DM, current smoking, hypertension, dyslipidemia, hsCRP≥2mg/L, family history) * TBR of \>1.6 of the MDS of the carotid/aorta at baseline. This baseline arterial TBR cutoff excludes the rare individual that lacks appreciable arterial inflammation. It is notable that while 5-10% of uninfected individuals will have lower TBRs, it is rare that an HIV infected individual will fall below this range. * Female subjects must either be of non-childbearing potential as defined by menopause with amenorrhea for \>2 years, bilateral oophorectomy, or agree to use adequate contraception throughout the study and for at least one month following termination and have a negative pregnancy test at screening prior to the first dose of drug. * Males must use at least one method of contraception throughout the study. Exclusion Criteria: * Pregnant/nursing women * Uncontrolled hypertension or diabetes requiring insulin * AST/ALT or alkaline phosphatase \>2x ULN * Cancer within the last 5 years with exception of squamous cell carcinoma and basal cell carcinoma * Nephrotic syndrome or eGFR \<60 mL/min/1.73m2 * Cytopenias which include 1) WBC \<3.5 x103/uL 2) Platelet \<120 x103/uL 3) ANC \<1.5 x103/uL, and absolute lymphocytes \<0.8 x 103/uL * Anemia as fined by \<10 g/dL * Evidence of tuberculosis infection at screening within 30 days prior to screening. * Family history of long QT syndrome, using medication that prolongs QT internal, OR evidence of prolonged QT of \>470 msec as evidenced by ECG * Acute systemic infection within 30 days * On additional immunosuppressant or immunomodulatory therapies