Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis

Universitair Ziekenhuis Brussel1,000 enrolled

Overview

The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who received prolonged sedation (\>24h) with sevoflurane.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Nephrogenic Diabetes Insipidus

Interventions

SevofluraneDRUG

Sevoflurane administration to sedate the patient

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Sevoflurane administration \>24h * 18 years and older Exclusion Criteria: * \< 18 years old * Pre-existing diabetes insipidus * Use of drugs at risk for diabetes insipidus (including lithium, cisplatin) * Hypercalcemia (persistently \>2.75 mmol/L) * Pituitary or acute brain surgery * Patients requiring continuous renal replacement therapy * Pregnancy

Locations (1)

UZ Brussel

Jette, Brussels Capital, Belgium

Outcomes

Primary Outcomes

Nephrogenic Diabetes Insipidus prevalence

How many patients under sevoflurane sedation ultimately develop NDI? NDI confirmed by demonstrating the absence of a urine concentrating response to exogenous Arginine Vasopressine.

Time frame: up to 8 weeks

Secondary Outcomes

Number of patients that develop risk factors of NDI

Number of patients that develop risk factors (electrolyte disorder, urinary obstruction) for NDI.

Time frame: up to 8 weeks

Amount of time patient was placed under sevoflurane sedation.

How long are they under sevoflurane sedation.

Time frame: up to 8 weeks

Number of patients with electrolyte abnormalities as assessed by lab results.

Lab results of hematology and chemistry labs show an electrolyte imbalance.

Time frame: during hospitalization, up to 8 weeks.

Number of patients with excessive urine output

Amount of urine output: \>40 ml/kg/24h

Time frame: during hospitalization, up to 8 weeks.

Number of patients with an abnormal physical examination.

Typical physical symptoms of (N)DI: tired, lethargic, tachycardia, tachypnea, hypotension and dry mucous membranes.

Time frame: during hospitalization, up to 8 weeks.

Number of patients with urine with an abnormal osmolality

Lab testing of urine: osmolality \< 300 mosm/kg

Time frame: during hospitalization, up to 8 weeks.

Data from ClinicalTrials.gov

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