The trial will include 75 patients with evident or suspected ischemic heart disease refered to Department of Nuclear Medicine \& PET Centre, Aarhus University Hospital, for perfusion imaging by 15O-H2O PET/CT scan of the heart during rest and stress. Instead of the clinical scan participants will undergo perfusion imaging by 15O-H2O PET/MR. The clinician will receive diagnostic information based on the 15O-H2O PET scan as if the patient had not participated in the study. As such, the study has no influence on the diagnostics or treatments of the patient. Data from the scans will be used to compare 15O-H2O PET with cardiac MR for evaluation of myocardial perfusion. Follow up will be done for up to 10 years in regards to major cardiovascular events in order to determine the prognostic value of the scan.
Study Type
OBSERVATIONAL
Enrollment
73
Aarhus University Hospital
Aarhus, Aarhus N, Denmark
Difference in myocardial blood flow
The difference in assessed myocardial blood flow as measured by 15O-H2O PET and MR
Time frame: 2 years
Prognostic value within 10 years
Number of participants who experience a major adverse cardiac event within 10 years of follow-up.
Time frame: 10 years
Difference in coronary flow reserve
The difference in assessed myocardial blood flow as measured by 15O-H2O PET and MR
Time frame: 2 Years
Difference in predictive value
The difference in predictive value of myocardial blood flow measurements as measured by 15O-H2O PET and MR
Time frame: 10 years
Difference in left ventricular end-systolic volume
The difference in left ventricular end-systolic volume as measured by 15O-H2O PET and MR
Time frame: 2 years
Difference in left ventricular end-diastolic volume
The difference in left ventricular end-diastolic volume as measured by 15O-H2O PET and MR
Time frame: 2 years
Difference in right ventricular end-systolic volume
The difference in right ventricular end-systolic volume as measured by 15O-H2O PET and MR
Time frame: 2 years
Difference in right ventricular end-diastolic volume
The difference in right ventricular end-diastolic volume as measured by 15O-H2O PET and MR
Time frame: 2 years
Difference in left ventricular mass
The difference in left ventricular mass as measured by 15O-H2O PET and MR
Time frame: 2 years
Amount of scar tissue
Scar tissue assessment as measured by MR
Time frame: 2 years
Pulmonary transit time
Pulmonary transit time as measured by 15O-H2O PET
Time frame: 2 years
Pulmonary perfusion
Pulmonary perfusion as measured by 15O-H2O PET
Time frame: 2 years
Prognostic value within 3,5 years
Number of participants who experience a major adverse cardiac event within 3,5 years of follow-up.
Time frame: 5 years
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