The purpose of this study is to assess the feasibility and efficacy of real-time fMRI neurofeedback for rumination.
Neuroimaging MRI techniques for measuring brain structure, tissue composition, and Blood Oxygenation Level Dependent functional Magnetic Resonance imaging (BOLD fMRI) will be used to measure task-dependent and task-independent brain hemodynamic and electrophysiological changes in human subjects with major depressive disorders (MDD). After being informed about the study and potential risks, all participants giving written informed consent will undergo one session of the cognitive process-based fMRI neurofeedback (CNF) targeting the rumination-related brain functional connectivity, and a one-week follow-up. Participants will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to Active (receiving feedback from their own brain activity) or Sham (receiving artificially generated feedback).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
44
The session will be done on an individual basis. The active group will receive neurofeedback training from the rumination-related brain functional connectivity.
The session will be done on an individual basis. The sham group will receive neurofeedback training from an artificially generated random feedback signal.
Laureate Institute for Brain Research
Tulsa, Oklahoma, United States
Functional connectivity change between precuneus and right temporoparietal junction (rTPJ)
Functional connectivity between precuneus and rTPJ will be calculated and evaluated using fMRI BOLD percent signal change.
Time frame: Through study completion (average: 2 weeks)
Changes in Brooding subscale of Ruminative Responses Scale (RRS) scores
The RRS Brooding subscale is a self-report scale to measure brooding ruminative responses. A higher score indicates higher brooding ruminative responses with a maximum score of 20 and a minimum score of 5.
Time frame: Through study completion (average: 2 weeks)
Changes in Depression subscale of Ruminative Responses Scale (RRS) scores
The RRS Depression subscale is a self-report scale to measure depressive ruminative responses. A higher score indicates higher ruminative responses with a maximum score of 48 and a minimum score of 12.
Time frame: Through study completion (average: 2 weeks)
Changes in Reflection subscale of Ruminative Responses Scale (RRS) scores
The RRS Reflection subscale is a self-report scale to measure reflective ruminative responses. A higher score indicates higher ruminative responses with a maximum score of 20 and a minimum score of 5.
Time frame: Through study completion (average: 2 weeks)
Changes in sum of Brooding and Depression subscales of Ruminative Responses Scale (RRS) scores
The RRS Brooding and Depression subscales are a self-report scale to measure brooding and depressive ruminative responses. A higher score indicates higher ruminative responses with a maximum score of 68 and a minimum score of 17.
Time frame: Through study completion (average: 2 weeks)
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Changes in total score of Ruminative Responses Scale (RRS) scores
The RRS is a self-report scale to measure ruminative responses. A higher score indicates higher ruminative responses with a maximum score of 88 and a minimum score of 22.
Time frame: Through study completion (average: 2 weeks)