Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis

Inclusion Criteria: * Patients with a clinical, radiographic and/or laboratory study confirmed chronic osteomyelitis of long bones * Patients who are physically and mentally willing and able to comply with postoperative functional evaluation. * Patients that can read and understand the Dutch language. Exclusion Criteria: * Patients with an diabetic ulcer related chronic osteomyelitis * Patients that are pregnant. * Patients who are unwilling to cooperate with the study protocol and follow-up schedule. * Patients who, as judged by the surgeon, are mentally incompetent or are likely to be non-compliant with the prescribed post-operative routine and follow-up evaluation schedule. * Patients with malignancy - active malignancy within last 1 year * Patients known with a diagnosed systemic disease that would affect the subject's welfare or overall outcome of the study (severe osteoporosis requiring medication, Paget's disease, renal osteodystrophy,hypercalcemia ) or is immunologically suppressed, or receiving steroids in excess of physiologic dose. * Patients with a neuromuscular or neurosensory deficit which would limit the ability to assess the performance of the device or the patient has a neurological deficit which interferes with the patient's ability to limit weight bearing or places an extreme load on the implant during the healing period. * Patients with systemic or metabolic disorders leading to progressive bone deterioration * Patients with other concurrent illnesses that are likely to affect their outcome such as all autoimmune diseases (including RA), sickle cell anaemia, systemic lupus erythematosus, psoriasis, not controlled type 1/2 diabetes or renal disease requiring dialysis. * Patients with a known sensitivity to device materials * Patients that are an alcohol and/or drug abuser as defined by currently undergoing treatment for alcohol and/or drug abuse