Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment

Inclusion Criteria: * Patients with suspected meningitis : the patient has a new fever (\>38.5℃), accompanied by ≥1 of the following manifestations： 1. Stiff neck 2. Change in state of consciousness 3. Other signs of meningitis: such as meningeal irritation. * Patients with suspected encephalitis: Unexplained changes in the state of consciousness for more than 24 hours (including lethargy, agitation, personality changes, etc.) or accompanied by recent memory impairment, with the following ≥1 manifestations: 1. Fever during the course of the disease (≥ 38℃); (oral temperature) 2. Convulsions or focal neurological symptoms; 3. Increase in the number of cerebrospinal fluid cells (\>4\*10\^6/L); 4. Abnormal EEG that meets the manifestations of encephalitis and cannot be attributed to other reasons 5. Imaging suggests encephalitis (CT or MRI) * Have not received effective anti-infective treatment yet * Have an identifiable address and live in the area during treatment. * Suspected encephalitis/meningitis patients who are willing to participate in trial treatment and follow-up and can give informed consent (if the subject is illiterate, sign or hearing consent is required). * Willing to comply with follow-up research procedures. Exclusion Criteria: * Known breastfeeding or pregnancy * Failure to comply with treatment or follow-up time; * The researcher believes that there are any conditions (social or medical) that allow subjects to participate in unsafe; * Participating in other clinical studies * Insufficient cerebrospinal fluid or blood samples * Clinically diagnosed infections, tumors or other neurological diseases