Evaluate and study the immunologic changes to the ocular surface in cancer patients.
This is a longitudinal natural history study to evaluate and study the immunologic changes to the ocular surface in cancer patients. Two groups of subjects will be recruited for the study: 1) Pre-bone marrow transplant cancer patients. They will be evaluated every 3 months for 2 years.2) Normal control patients. They will be evaluated every 6 months for the duration of the study. During each study visit, in addition to standard of care exams, certain biological specimens ( ocular surface wash, mucocellular material, corneal filaments, or impression cytology of conjunctiva, blood, or serum) will be collected.
Study Type
OBSERVATIONAL
Enrollment
150
During each visit, in addition to standard of care exams, certain biological specimens ( ocular surface wash, mucocellular material, corneal filaments or impression cytology of conjunctiva, blood or serum) will be collected.
Geenebaum Cancer Center, University of Maryland Medical Center
Baltimore, Maryland, United States
RECRUITING1. Risk factors and markers for developing eye diseases
Number of patients with the risks and markers who have developed the eye diseases during the study
Time frame: Up to 4 years
2. The mechanisms of eye damage
Number of patients who have eye damage during the study
Time frame: Up to 4 years
The drug acting targets
Number of patients who have eye diseases with eye surface changes after the treatment during the study.
Time frame: Up to 4 years
The effect of ocular Graft-vs-Host Disease on the eye
Number of patients who have eye surface changes with Graft-vs-Host Disease during the study
Time frame: Up to 4 years
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