Potential Benefits of Laser Treatment on Skin Blood Flow and Sweating in Burn Survivors

University of Texas Southwestern Medical Center4 enrolled

Overview

The purpose of this study is to examine effects of laser therapy on blood flow and sweating responses in burn-injured skin.

This is a longitudinal study in which the effects of laser therapy on cutaneous vascular responses and sweating of the treated areas are assessed. Specifically, burn survivors who will undergo standard of care laser therapy to treat burn-related scars will perform whole-body heating and local heating procedures prior to the initiation of laser therapy, at an intermediate point during the laser therapy regimen, and upon conclusion of the laser therapy regimen. For this pilot investigation a placebo will not be incorporated. Primary outcome variables will be skin blood flow and sweating responses from skin treated with laser therapy and adjacent untreated/uninjured skin.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Burn Injury

Interventions

fractional CO2 laserDEVICE

Standard of care laser treatment of burn-related injuries will be performed. This protocol assesses the effects of those treatments on skin blood flow and sweating responses.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 years old * Experience a severe burn injury that warrant laser therapy. * Free of any significant underlying medical problems based upon a detailed medical history and physical exam Exclusion Criteria: * Known heart disease * Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia. * Abnormality detected on routine screening suggestive of cardiac ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram. * Subject with a body mass index \>35 kg/m2 * Pregnant or planning to become pregnant within the subsequent 6 months.

Locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Outcomes

Primary Outcomes

Skin blood flow

Primary outcome variables will be skin blood flow and sweating responses from skin treated with laser therapy and adjacent untreated/uninjured skin.

Time frame: Upwards to 6 months after the final laser treatment

Data from ClinicalTrials.gov

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