Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks

Inclusion Criteria: * 1\. Age ≥18 years old and \<65 years old at the time of signing the informed consent form, regardless of gender; 2\. Diagnose patients who meet the criteria for the diagnosis of migraine without aura in the third trial version of the International Classification of Headache Diseases (ICHD-Ⅲ(β)) launched by the International Headache Association, and the degree is moderate or severe; 3\. The age of the patient's first migraine attack should be less than 50 years old, and must meet 5 or more migraine attacks without aura or a history of migraine without aura ≥ 1 year; 4\. The number of moderate or severe migraine attacks ≤6 and ≥1 per month within the first 3 months of enrollment, and at least a 48-hour headache interval; 5\. Ability to distinguish migraine patients from other types of headaches during headache attacks; 6\. Female patients who have not had unprotected sex in the 15 days before screening, and patients (regardless of men and women) who have no childbirth plans during the trial period and within 6 months after the end of the trial; 7\. Patients who have the ability to cooperate in observing curative effects and adverse events, and record headache diaries; 8\. Before starting any detailed procedures of this study, the patient has the ability to understand and sign a written informed consent form approved by the ethics committee Exclusion Criteria: * 1\. Patients with migraine with aura, including but not limited to patients with brainstem migraine with aura and patients with hemiplegic migraine; 2\. Patients with average headache time ≥15 days per month in the 3 months before the test; 3\. Patients who have taken painkillers for a long time or overuse of painkillers (take painkillers for more than 10 days a month for 3 consecutive months); 4\. Abnormal renal function: creatinine value\> upper limit of normal value; 5\. Patients with a history of severe liver disease or patients with significantly abnormal liver function: alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ≥ 1.5 times the upper limit of normal or total bilirubin (TBIL) )≥1.5 times the upper limit of the normal value; 6\. History of major mental and neurological diseases such as depression and epilepsy; 7\. Patients who have taken central sedatives for a long time, such as barbiturates and benzodiazepines, including diazepam, lorazepam, etc.; 8\. Patients with severe cardiovascular diseases, such as coronary artery bypass surgery, or patients with a history of one of the following diseases, including but not limited to ischemic heart disease, such as angina (including Platts variant angina), Patients with a history of myocardial infarction, arrhythmia (such as pre-excitation syndrome) or disease-related symptoms, signs, or a significant ECG abnormal change; 9\. Patients with severe cerebrovascular diseases, including but not limited to cerebral ischemia, cerebral hemorrhage diseases; 10\. With severe peripheral vascular disease, such as Raynaud's syndrome; 11\. Patients whose blood pressure cannot be effectively controlled after drug treatment, systolic blood pressure (SBP)\>140mmHg or diastolic blood pressure (DBP)\>90mmHg; 12\. Take ergotamine or ergot derivatives (such as dihydroergotamine or ergonovine) or other 5-HT1 receptor agonists within 7 days before randomization; 13\. Patients who have taken MAOI within 14 days before screening; 14\. Patients who cannot stop using anticoagulant drugs (such as warfarin) or antiplatelet drugs (such as aspirin) during the trial; 15\. Patients who have previously undergone gastric resection or bypass surgery, or patients with a history of gastrointestinal bleeding, ulcers, or perforation; 16\. Patients suffering from sinusitis; 17\. Regularly take drugs for preventing headache attacks for more than 2 weeks before randomization, including but not limited to flunarizine, topiramate and Chinese patent medicines with similar effects; 18\. Known to triptan drugs, NSAIDs or their pharmaceutical excipients Patients with allergies, or have had aspirin asthma or aspirin triad (aspirin allergy, asthma, and nasal polyps); 19\. For patients with alcohol abuse and drug abuse, the standard for alcohol abuse is: drinking an average of more than 28 units per week (a unit of alcohol is equivalent to 250 mL of beer, 125 mL of wine or 20 mL of spirits or enthusiastic alcoholism); There are two types of drugs: one is narcotic drugs, such as heroin, marijuana and cannabis resin, opiates and morphine preparations, codeine, etc.; the other is psychotropic drugs, such as various hallucinogens and tetrahydrocannabinol, central stimulants Drugs, barbiturates, benzodiazepines, etc.; 20\. Patients who are pregnant, breastfeeding, or have a childbearing plan during the study period, including female patients of childbearing age who have a positive pregnancy test; 21\. Patients who have participated in any other clinical trials within 3 months before participating in this trial, and who plan to participate in other clinical trials of other drugs; 22\. The patient may not be able to complete the trial due to reasons, or the investigator believes that the patient is not suitable to participate in this trial. "