The estimates risks and benefits of the percutaneous kidney biopsy have been reported mainly from retrospective studies. So far no prospective multicentre studies has been designed to identify rates of biopsy related complications. The aim of this prospective multicentre study was to evaluate safety and complication events related to biopsies on native kidney in Italy.
Kidney biopsies performed in 54 italian nephrology centres from 2012 to 2020 were included. Primary outcome of the study was any major complication, such as haemoglobin decrease more than 2 g/dL, macroematuria, gross ematoma, blood transfusion, artero-venous fistula, invasive intervention, pain, symptomatic hypotension, and/or rapid serum creatinine increase. Centre and individual patient risk predictors were analysed using multivariate logistic regression analysis.
Study Type
OBSERVATIONAL
Enrollment
5,304
San Giovanni di Dio Hospital
Agrigento, Italy
Giovanni XXIII pediatric Hospital
Bari, Italy
Policlinico Hospital
Bari, Italy
Any major post-biopsy complication event
The cecked of major post-biopsy complication events were clinically relevant hematomas, macrohematuria, decrease of haemoglobin levels after 24 hours \> 2 g /dL, the need for blood transfusion, a large and persistent AV fistula, a post-biopsy anuria, an increase in serum creatinine greater than 50% in the week following biopsy, the need for invasive post-biopsy procedure related to the procedure including nephrectomy, the death related to biopsy
Time frame: one week follow-up after native kidney biopsy
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S. Orsola Hospital
Bologna, Italy
Cannizzaro Hospital
Catania, Italy
S. Camillo Hospital
Chieti, Italy
Santa Croce Hospital
Cuneo, Italy
Maria SS. Addolorata Hospital
Eboli, Italy
University Hospital
Foggia, Italy
Policlinico Hospital
Messina, Italy
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