Changes in Cerebral Oxygenation and Cognitive Functions

Zonguldak Bulent Ecevit University40 enrolled

Overview

The present study aimed to assess the influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by using near-infrared spectroscopy and postoperative cognitive function in patients undergoing nasal surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypotension; Controlled Cognitive Dysfunction

Interventions

EsmololDRUG

NitroglycerinDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * written informed consent * patients with ASA physical status of I-II * aged 18-65 years Exclusion Criteria: * Age under 18 or above 65 * ASA \> II * coagulation disorders * history of cardiovascular and cerebrovascular disease * poor Blood Pressure control * anemia, pregnancy, addiction to opioids * body mass index (BMI) \> 35 * intraoperative systolic BP \< 65 mmHg * surgical duration less than 30 minutes or more than 160 minutes * need for an intraoperative sympathomimetic drug and the use of other hypotensive drugs * preoperative Mini-Mental State Examination (MMSE) score of 23 or less.

Locations (1)

Zonguldak Bülent Ecevit University Medicine Faculty

Zonguldak, Kozlu, Turkey (Türkiye)

Outcomes

Primary Outcomes

effects of controlled hypotension on cerebral oxygen saturation

influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by measuring regional cerebral oxygen saturation using Near-Infrared Spectroscopy

Time frame: until end of the surgical procedure.

Secondary Outcomes

effects of controlled hypotension on cognitive function

influence of nitroglycerin and esmolol-induced hypotension on postoperative cognitive function using mini mental test score

Time frame: 24 hour before surgery and 24 hour after surgery

Data from ClinicalTrials.gov

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