The aim of this study is to develop a one-step diagnostic method for adrenal diseases, Patients with adrenal diseases including non-functioning adrenal adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Using mass spectrometry analysis based on a multisteroid panel, serum, urine, saliva, and hair samples of the patients will be analyzed. The diagnostic yield of each and combination of steroids will be evaluated.
Adrenal diseases consist of heterogenous diseases. To differentiate various adrenal diseases, multiple steps of diagnostic tests are needed. In this study, the investigators aimed to develop a one-step diagnostic method to differentiate various adrenal diseases using multisteroid panel. About 400 patients with adrenal diseases including non-functioning adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Serum, hair, saliva, and urine samples of the patients will be analyzed using mass spectrometry. Each and combination of multisteroid will be evaluated for diagnosing adrenal diseases.
Study Type
OBSERVATIONAL
Enrollment
400
Seoul National University Hospital
Seoul, Jongno-gu, South Korea
Diagnostic accuracy of multisteroid panel for differentiating adrenal diseases
* Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of Cushing's syndrome. * Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of primary aldosteronism. * Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of pheochromocytoma.
Time frame: Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made
Diagnostic accuracy of each steroid component for differentiating adrenal diseases
Evaluate how accurately each component of the steroid panel differentiate adrenal diseases. * Sensitivity (%) and specificity (%) of each steroid measures for adrenal Cushing's syndrome will be calculated. * Sensitivity (%) and specificity (%) of each steroid measures for primary aldosteronism will be calculated. * Sensitivity (%) and specificity (%) of each steroid measures for pheochromocytoma will be calculated.
Time frame: Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made
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