We clinically observed that some hemodialysis patients had corneal epithelial dryness, shedding, edema, and persistent epithelial nonunion after ocular surgery, which seriously affected the effect of surgery, and it is necessary to study the ocular surface characteristics of hemodialysis patients. In this study, we examined the ocular surface and analyzed and investigated the characteristics of the ocular surface in hemodialysis patients to provide a basis for ocular surface intervention or treatment in hemodialysis patients before ocular surgery in clinical practice.
This study is a clinical case-control study. A total of 36 hemodialysis patients and 36 normal subjects were randomly selected from the Nephrology Department of the First Affiliated Hospital of Jinan University .All the subjects in the hemodialysis group (n = 36, 72 eyes) and the normal group (n = 36, 72 eyes) were investigated with the OSDI scale, and then bilateral ocular surface examinations were performed with Keratograph5M eye surface comprehensive analyzer. Non-invasive tear meniscus height (NITMH), first tear film break-up time (FTBUT), average tear film break-up time (ATBUT), dry eye severity grade, tear film lipid layer analysis (distribution and color), tear film lipid layer thickness grade, meibomian gland opening blocking site, meibomian gland opening blocking analysis, meibomian gland opening secretion oil character score, eye redness index analysis (conjunctiva, ciliary shape), and meibomian gland absence area score were recorded.
Study Type
OBSERVATIONAL
Enrollment
36
Using ocular surface analyzer for Inspection
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, China
Non-invasive tear meniscus height
Maximum and minimum of Non-invasive tear meniscus height in millimetre，higher scores mean a better outcome.
Time frame: 1year
first tear film break-up time
Maximum and minimum of first tear film break-up time in Seconds，higher scores mean a better outcome.
Time frame: 1year
average tear film break-up time
Maximum and minimum of average tear film break-up time in Seconds，higher scores mean a better outcome.
Time frame: 1year
dry eye severity grade
Maximum and minimum of dry eye severity grade，higher scores mean a worse outcome.
Time frame: 1year
tear film lipid layer analysis (distribution and color)
Maximum and minimum of tear film lipid layer analysis (distribution and color)，higher scores mean a better outcome.
Time frame: 1year
tear film lipid layer thickness grade
Maximum and minimum of tear film lipid layer thickness grade,higher scores mean a better outcome.
Time frame: 1year
meibomian gland opening blocking site
Maximum and minimum of meibomian gland opening blocking site，higher scores mean a worse outcome.
Time frame: 1year
meibomian gland opening blocking analysis
Maximum and minimum of meibomian gland opening blocking analysis，higher scores mean a worse outcome.
Time frame: 1year
meibomian gland opening secretion oil character score
Maximum and minimum of meibomian gland opening secretion oil character score，higher scores mean a worse outcome.
Time frame: 1year
eye redness index analysis (conjunctiva, ciliary shape)
Maximum and minimum of eye redness index analysis (conjunctiva, ciliary shape)，higher scores mean a worse outcome.
Time frame: 1year
meibomian gland absence area score
Maximum and minimum of meibomian gland absence area score，higher scores mean a worse outcome.
Time frame: 1year
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