Effective nutrition strategies for combatting and/or preventing obesity still need to be identified. This has been the case despite the numerous and different approaches that have been taken. Potential targets for combatting/preventing obesity have been identified, but long-term solutions have not emerged. This study uses time restricted feeding to study the role of dietary protein in obesity prevention and/or treatment. The objectives are to determine the role of skeletal muscle mass as a driver of energy-sensing mechanisms and peripheral signals that regulate appetite and energy intake in overweight and obese adults and to determine the effects of protein timing on muscle mass to regulate appetite and energy intake in overweight and obese adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
90
Participants consume whey protein at the beginning of the eating period.
Participants consume ketogenic aid upon waking.
Time restricted feeding.
University of Arkansas
Fayetteville, Arkansas, United States
RECRUITINGBody composition
Body composition measured using dual x-ray absorptiometry to determine the ration of lean/fat-free mass to fat mass.
Time frame: Change is being assessed at baseline and final day (day 120) of the intervention.
Whole body protein turnover
Whole body protein turnover will be measured using 15N-alanine
Time frame: Change is being assessed at baseline and final day (day 120) of the intervention.
Muscle mass
Muscle mass will be measured using D3-creatine
Time frame: Change is being assessed at baseline and final day (day 120) of the intervention.
Body weight
Body weight will be measured in kilograms.
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks.
Sleep
Sleep will be assessed using wrist Actigraphy for sleep duration and total time in bed.
Time frame: Change is being assessed at baseline and 12 weeks
Sleep Quality
Sleep quality will be measured using the Pittsburgh Sleep Quality Index survey
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Mood
Mood will be assessed using the Profile of Mood States Questionnaire
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Grit
Grit will be assessed using the grit questionnaire.
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Self-reported physical activity
Physical activity will be measured using the iPAQ survey
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Dietary intake
Dietary intake will be measured using weighed, 3-day food records
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Fasting glucose
Glucose will be measured as mg/dl
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Hand grip
Hand grip will be measured using a dynamometer.
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
Amino acids and metabolites
Blood will be collected and plasma amino acids and metabolites will be assessed using commercially available kit for amino acid analysis for all circulating amino acids.
Time frame: Change is being assessed at baseline, 4, 8, and 12 weeks
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