The purpose of this study is to investigate the efficacy of dilution with glucose and prolonged injection time on dexamethasone 21-phosphate induced perineal irritation (include pian and pruritus).
Dexamethasone is a synthetic glucocorticoid, which may cause perineal irritation when given intravenously. The major clinical manifestations are pruritus and pain，and the incidence vary between 38%-71%. Some patients undergo spontaneous remission, while others develop into severe pain or pruritus. In clinical practice, dexamethasone is always diluted with glucose in many cases, but diluted dexamethasone in relieving dexamethasone induced perineal irritation has not been studied yet. The aim of this study was to investigate the efficacy of dilution with glucose on dexamethasone induced perineal irritation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
200
receive 2ml dexamethasone (5mg/ml)
receive 5ml dexamethasone (2mg/ml) diluted with 5% glucose
receive 10ml dexamethasone (1mg/ml) diluted with 5% glucose
The incidence of dexamethasone-induced perineal irritation
The investigators record the number of cases of dexamethasone-induced perineal irritation (pain or pruritus) and calculate the incidence
Time frame: During the first 3 min period after the injection of dexamethasone
Duration of perineal irritation
If perineal irritation occurs, the investigators will record its duration
Time frame: After the injection of dexamethasone, up to 5 minutes
The severity of perineal irritation
If perineal irritation occurs, the investigators will assess its severity by using Visual Analogue Scale (the minimum is 0 and the maximum is 10, and the higher scores mean a worse outcome)
Time frame: After the injection of dexamethasone, up to 5 minutes
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receive 20ml dexamethasone (0.5mg/ml) diluted with 5% glucose